1hk5: Difference between revisions
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<StructureSection load='1hk5' size='340' side='right'caption='[[1hk5]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='1hk5' size='340' side='right'caption='[[1hk5]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hk5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HK5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hk5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HK5 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=T44:3,5,3,5-TETRAIODO-L-THYRONINE'>T44</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk5 OCA], [https://pdbe.org/1hk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hk5 RCSB], [https://www.ebi.ac.uk/pdbsum/1hk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hk5 OCA], [https://pdbe.org/1hk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hk5 RCSB], [https://www.ebi.ac.uk/pdbsum/1hk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hk5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bhagavan | [[Category: Bhagavan NV]] | ||
[[Category: Bhattacharya | [[Category: Bhattacharya AA]] | ||
[[Category: Curry | [[Category: Curry S]] | ||
[[Category: Ghuman | [[Category: Ghuman J]] | ||
[[Category: Ha | [[Category: Ha CE]] | ||
[[Category: Petersen | [[Category: Petersen CE]] | ||
[[Category: Petitpas | [[Category: Petitpas I]] | ||
[[Category: Zunszain | [[Category: Zunszain PA]] | ||