1a7z: Difference between revisions

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[[Image:1a7z.png|left|200px]]


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==CRYSTAL STRUCTURE OF ACTINOMYCIN Z3==
The line below this paragraph, containing "STRUCTURE_1a7z", creates the "Structure Box" on the page.
<StructureSection load='1a7z' size='340' side='right'caption='[[1a7z]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A7Z FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNZ:BENZENE'>BNZ</scene>, <scene name='pdbligand=CTH:4-CHLOROTHREONINE'>CTH</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=H5M:TRANS-3-HYDROXY-5-METHYLPROLINE'>H5M</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=POM:CIS-5-METHYL-4-OXOPROLINE'>POM</scene>, <scene name='pdbligand=PRD_000009:Actinomycin+Z3'>PRD_000009</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
{{STRUCTURE_1a7z|  PDB=1a7z  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7z OCA], [https://pdbe.org/1a7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a7z RCSB], [https://www.ebi.ac.uk/pdbsum/1a7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7z ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Untwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture).


===CRYSTAL STRUCTURE OF ACTINOMYCIN Z3===
Crystal Structures of Actinomycin D and Actinomycin Z3.,Schafer M, Sheldrick GM, Bahner I, Lackner H Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17&lt;2381::AID-ANIE2381&gt;3.0.CO;2-L. PMID:29710967<ref>PMID:29710967</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
[[1a7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7Z OCA].
<div class="pdbe-citations 1a7z" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces fradiae]]
[[Category: Streptomyces fradiae]]
[[Category: Schafer, M.]]
[[Category: Schafer M]]
[[Category: Actinomycin]]
[[Category: Actinomycin d]]
[[Category: Antibiotic]]
[[Category: Anticancer]]
[[Category: Antitumor]]
[[Category: Chromophore]]
[[Category: Depsipeptide]]

Latest revision as of 10:45, 15 November 2023

CRYSTAL STRUCTURE OF ACTINOMYCIN Z3CRYSTAL STRUCTURE OF ACTINOMYCIN Z3

Structural highlights

1a7z is a 2 chain structure with sequence from Streptomyces fradiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.95Å
Ligands:, , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Untwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture).

Crystal Structures of Actinomycin D and Actinomycin Z3.,Schafer M, Sheldrick GM, Bahner I, Lackner H Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L. PMID:29710967[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Schafer M, Sheldrick GM, Bahner I, Lackner H. Crystal Structures of Actinomycin D and Actinomycin Z3. Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L. PMID:29710967 doi:<2381::AID-ANIE2381>3.0.CO;2-L http://dx.doi.org/10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L

1a7z, resolution 0.95Å

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