5mph: Difference between revisions

<StructureSection load='5mph' size='340' side='right'caption='[[5mph]], [[Resolution|resolution]] 2.34&Aring;' scene=''>

<table><tr><td colspan='2'>[[5mph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MPH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.337&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mph OCA], [https://pdbe.org/5mph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mph RCSB], [https://www.ebi.ac.uk/pdbsum/5mph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mph ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GRHL1_HUMAN GRHL1_HUMAN] Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed:12175488).[UniProtKB:Q921D9]<ref>PMID:12175488</ref> <ref>PMID:18288204</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Heinemann U]]

[[Category: Ibraimi I]]

[[Category: Ming Q]]

[[Category: Roske Y]]

[[Category: Schmidt-Ott KM]]

[[Category: Schuetz A]]

[[Category: Walentin K]]