8p7i: Difference between revisions

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-'''Unreleased structure'''
-The entry 8p7i is ON HOLD
+==The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes==
+<StructureSection load='8p7i' size='340' side='right'caption='[[8p7i]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8p7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6fei 6fei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P7I FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=X3E:(2~{S},6~{R})-2,6-dimethyl-1,3-dioxane-4,4-diol'>X3E</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p7i OCA], [https://pdbe.org/8p7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p7i RCSB], [https://www.ebi.ac.uk/pdbsum/8p7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p7i ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
-Authors: Dym, O., Aggarwal, N., Ashani, Y., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Sussman, J.L.
+==See Also==
+*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
-Description: The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Hamer Rogotner, S]]
+[[Category: Brevundimonas diminuta]]
-[[Category: Albeck, S]]
+[[Category: Large Structures]]
-[[Category: Unger, T]]
+[[Category: Aggarwal N]]
-[[Category: Silman, I]]
+[[Category: Albeck S]]
-[[Category: Ashani, Y]]
+[[Category: Ashani Y]]
-[[Category: Sussman, J.L]]
+[[Category: Dym O]]
-[[Category: Aggarwal, N]]
+[[Category: Hamer Rogotner S]]
-[[Category: Dym, O]]
+[[Category: Silman I]]
+[[Category: Sussman JL]]
+[[Category: Unger T]]