5czu: Difference between revisions
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==Crystal structure of FeCat-Fn== | |||
<StructureSection load='5czu' size='340' side='right'caption='[[5czu]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5czu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CZU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LF:N-[2-[2,5-BIS(OXIDANYLIDENE)PYRROL-1-YL]ETHYL]-2,3-BIS(OXIDANYL)BENZAMIDE'>4LF</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5czu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czu OCA], [https://pdbe.org/5czu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5czu RCSB], [https://www.ebi.ac.uk/pdbsum/5czu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5czu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A set of three catecholamide ligands mimicking the structure of enterobactin was constructed on ferritin, where the 3-fold symmetric arrangement of the monomer subunits served as a foundation to form a coordination space. Similar to enterobactin, the ligands showed strong affinity for the ferric ion and formed a tris-catechoyl complex. Crystallography revealed that the complex was embedded in the entrance of the 3-fold axis channel. | |||
Construction of an enterobactin analogue with symmetrically arranged monomer subunits of ferritin.,Nakajima H, Kondo M, Nakane T, Abe S, Nakao T, Watanabe Y, Ueno T Chem Commun (Camb). 2015 Dec 4;51(93):16609-12. doi: 10.1039/c5cc06904a. Epub, 2015 Sep 25. PMID:26404005<ref>PMID:26404005</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5czu" style="background-color:#fffaf0;"></div> | ||
[[Category: Abe | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Ferritin 3D structures|Ferritin 3D structures]] | ||
[[Category: Nakane | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Equus caballus]] | |||
[[Category: Large Structures]] | |||
[[Category: Abe S]] | |||
[[Category: Kondo M]] | |||
[[Category: Nakajima H]] | |||
[[Category: Nakane T]] | |||
[[Category: Nakao T]] | |||
[[Category: Ueno T]] | |||
[[Category: Watanabe Y]] | |||