5b40: Difference between revisions

<StructureSection load='5b40' size='340' side='right' caption='[[5b40]], [[Resolution|resolution]] 3.33&Aring;' scene=''>

<table><tr><td colspan='2'>[[5b40]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B40 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b40 OCA], [http://pdbe.org/5b40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b40 RCSB], [http://www.ebi.ac.uk/pdbsum/5b40 PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> 

== References ==

[[Category: Horikoshi, N]]

[[Category: Kurumizaka, H]]

[[Category: Machida, S]]

[[Category: Nishiyama, Y]]

[[Category: Sekine, S]]

[[Category: Chromatin]]

[[Category: Histone modification]]

[[Category: Ubiquitin]]