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==Crystal structure of DAAO(Y228L/R283G) variant (S-methylbenzylamine binding form)== | ==Crystal structure of DAAO(Y228L/R283G) variant (S-methylbenzylamine binding form)== | ||
<StructureSection load='4yjf' size='340' side='right' caption='[[4yjf]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4yjf' size='340' side='right'caption='[[4yjf]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4yjf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YJF OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4yjf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YJF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=98B:(1S)-1-PHENYLETHANAMINE'>98B</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yjf OCA], [https://pdbe.org/4yjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yjf RCSB], [https://www.ebi.ac.uk/pdbsum/4yjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yjf ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | ||
==See Also== | |||
*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Asano | [[Category: Sus scrofa]] | ||
[[Category: Ishitsubo | [[Category: Asano Y]] | ||
[[Category: Kawahara | [[Category: Ishitsubo E]] | ||
[[Category: Nakano | [[Category: Kawahara N]] | ||
[[Category: Tokiwa | [[Category: Nakano S]] | ||
[[Category: Yasukawa | [[Category: Tokiwa H]] | ||
[[Category: Yasukawa K]] | |||
Latest revision as of 18:35, 8 November 2023
Crystal structure of DAAO(Y228L/R283G) variant (S-methylbenzylamine binding form)Crystal structure of DAAO(Y228L/R283G) variant (S-methylbenzylamine binding form)
Structural highlights
FunctionOXDA_PIG Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. See Also |
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