4rud: Difference between revisions
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<StructureSection load='4rud' size='340' side='right'caption='[[4rud]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='4rud' size='340' side='right'caption='[[4rud]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4rud]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUD FirstGlance]. <br> | <table><tr><td colspan='2'>[[4rud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Micrurus_fulvius Micrurus fulvius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUD FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rud OCA], [https://pdbe.org/4rud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rud RCSB], [https://www.ebi.ac.uk/pdbsum/4rud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rud ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rud OCA], [https://pdbe.org/4rud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rud RCSB], [https://www.ebi.ac.uk/pdbsum/4rud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rud ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/3SXB_MICFL 3SXB_MICFL] Postsynaptic neurotoxin that produces potent, and completely reversible, postsynaptic neuromuscular blockade, as well as broad spectrum inhibition of human muscle and neuronal nicotinic acetylcholine receptors (nAChRs). Inhibition is potent or moderate, depending on the receptor (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE (IC(50)=2.56 uM), alpha-4-beta-2/CHRNA4-CHRNB2 (IC(50)=1.8 uM), alpha-7/CHRNA7 (IC(50)=7 uM), and alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=12.6 uM)). Acts as a competitive antagonist of ACh. Binds to chicken muscle-type nicotinic acetylcholine receptor (AChR) with high potency compared with the cloned human receptor. Unlike short-chain alpha-3FTxs that only bind to muscle nAChRs, this toxin utilizes dimerization to expand its pharmacological targets to block neuronal nAChRs.[UniProtKB:U3FAE1] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Micrurus fulvius]] | ||
[[Category: | [[Category: Jobichen C]] | ||
[[Category: | [[Category: Sivaraman J]] | ||