4qy1: Difference between revisions
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==Structure of H10 from human-infecting H10N8 in complex with avian receptor== | ==Structure of H10 from human-infecting H10N8 in complex with avian receptor== | ||
<StructureSection load='4qy1' size='340' side='right' caption='[[4qy1]], [[Resolution|resolution]] 2.59Å' scene=''> | <StructureSection load='4qy1' size='340' side='right'caption='[[4qy1]], [[Resolution|resolution]] 2.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qy1]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QY1 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4qy1]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QY1 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.594Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qy1 OCA], [https://pdbe.org/4qy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qy1 RCSB], [https://www.ebi.ac.uk/pdbsum/4qy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qy1 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A059T4A1_9INFA A0A059T4A1_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046810] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 16: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4qy1" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bi | [[Category: Influenza A virus]] | ||
[[Category: Gao | [[Category: Large Structures]] | ||
[[Category: Huang | [[Category: Bi Y]] | ||
[[Category: Li | [[Category: Gao GF]] | ||
[[Category: Liu | [[Category: Huang C]] | ||
[[Category: Qi | [[Category: Li X]] | ||
[[Category: Shi | [[Category: Liu J]] | ||
[[Category: Shu | [[Category: Qi J]] | ||
[[Category: Sun | [[Category: Shi Y]] | ||
[[Category: Wang | [[Category: Shu Y]] | ||
[[Category: Wang | [[Category: Sun H]] | ||
[[Category: Wu | [[Category: Wang F]] | ||
[[Category: Yan | [[Category: Wang M]] | ||
[[Category: Zhang | [[Category: Wu Y]] | ||
[[Category: Zhou | [[Category: Yan J]] | ||
[[Category: Zhang W]] | |||
[[Category: Zhou J]] | |||