4q9u: Difference between revisions

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 ==Crystal structure of the Rab5, Rabex-5delta and Rabaptin-5C21 complex==
-<StructureSection load='4q9u' size='340' side='right' caption='[[4q9u]], [[Resolution|resolution]] 4.62&Aring;' scene=''>
+<StructureSection load='4q9u' size='340' side='right'caption='[[4q9u]], [[Resolution|resolution]] 4.62&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4q9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q9U FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4q9u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q9U FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n3x|4n3x]], [[4n3y|4n3y]], [[4n3z|4n3z]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.618&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RABGEF1, RABEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RAB5A, RAB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RABEP1, RAB5EP, RABPT5, RABPT5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q9u OCA], [https://pdbe.org/4q9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q9u RCSB], [https://www.ebi.ac.uk/pdbsum/4q9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q9u ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q9u OCA], [http://pdbe.org/4q9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q9u RCSB], [http://www.ebi.ac.uk/pdbsum/4q9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q9u ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/RABX5_HUMAN RABX5_HUMAN]] Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).<ref>PMID:9323142</ref> <ref>PMID:11452015</ref> <ref>PMID:15339665</ref>  [[http://www.uniprot.org/uniprot/RABE1_HUMAN RABE1_HUMAN]] Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.<ref>PMID:8521472</ref> <ref>PMID:10698684</ref> <ref>PMID:11452015</ref> <ref>PMID:12773381</ref>  [[http://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN]] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref>
+[https://www.uniprot.org/uniprot/RABX5_HUMAN RABX5_HUMAN] Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).<ref>PMID:9323142</ref> <ref>PMID:11452015</ref> <ref>PMID:15339665</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 18: @@
 </div>
 <div class="pdbe-citations 4q9u" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Rab5 GDP/GTP exchange factor|Rab5 GDP/GTP exchange factor]]
+*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Ding, J]]
+[[Category: Large Structures]]
-[[Category: Zhang, T]]
+[[Category: Ding J]]
-[[Category: Zhang, Z]]
+[[Category: Zhang T]]
-[[Category: Coiled-coil]]
+[[Category: Zhang Z]]
-[[Category: Early endosome]]
-[[Category: Effector]]
-[[Category: Endocytosis]]
-[[Category: Gef]]
-[[Category: Gef activity]]
-[[Category: Rab5]]
-[[Category: Rabaptin-5]]
-[[Category: Rabex-5]]
-[[Category: Small gtpase]]
-[[Category: Vps9]]