4op9: Difference between revisions

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-{{STRUCTURE_4op9|  PDB=4op9  |  SCENE=  }}
-===Urate OXIDASE IN COMPLEX WITH 8-AZAXANTHINE===
-==Function==
+==Urate OXIDASE IN COMPLEX WITH 8-AZAXANTHINE==
-[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
+<StructureSection load='4op9' size='340' side='right'caption='[[4op9]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4op9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OP9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4op9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4op9 OCA], [https://pdbe.org/4op9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4op9 RCSB], [https://www.ebi.ac.uk/pdbsum/4op9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4op9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Urate oxidase from Aspergillus flavus is a 135 kDa homo-tetramer which has a hydrophobic cavity buried within each monomer and located close to its active site. Crystallographic studies under moderate gas pressure and high hydrostatic pressure have shown that both gas presence and high pressure would rigidify the cavity leading to an inhibition of the catalytic activity. Analysis of the cavity volume variations and functional modifications suggest that the flexibility of the cavity would be an essential parameter for the active site efficiency. This cavity would act as a connecting vessel to give flexibility to the neighboring active site, and its expansion under pure oxygen pressure reveals that it might serve as a transient reservoir on its pathway to the active site.
-==About this Structure==
+Functional relevance of the internal hydrophobic cavity of urate oxidase.,Colloc'h N, Prange T FEBS Lett. 2014 May 2;588(9):1715-9. doi: 10.1016/j.febslet.2014.03.017. Epub, 2014 Mar 18. PMID:24657440<ref>PMID:24657440</ref>
-[[4op9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OP9 OCA].
-[[Category: Factor independent urate hydroxylase]]
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Prange, T.]]
+</div>
-[[Category: H, N Colloc.]]
+<div class="pdbe-citations 4op9" style="background-color:#fffaf0;"></div>
-[[Category: Homotetramer]]
-[[Category: Oxidoreductase]]
+==See Also==
-[[Category: Peroxisome]]
+*[[Urate oxidase 3D structures|Urate oxidase 3D structures]]
-[[Category: Purisme metabolism]]
+== References ==
-[[Category: T-fold domain]]
+<references/>
-[[Category: Uric acid]]
+__TOC__
+</StructureSection>
+[[Category: Aspergillus flavus]]
+[[Category: Large Structures]]
+[[Category: Colloc'h N]]
+[[Category: Prange T]]