4nqy: Difference between revisions

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==The reduced form of MJ0499==
==The reduced form of MJ0499==
<StructureSection load='4nqy' size='340' side='right' caption='[[4nqy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4nqy' size='340' side='right'caption='[[4nqy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nqy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NQY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kp1|4kp1]], [[4kp2|4kp2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqy OCA], [http://pdbe.org/4nqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nqy RCSB], [http://www.ebi.ac.uk/pdbsum/4nqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqy OCA], [https://pdbe.org/4nqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nqy RCSB], [https://www.ebi.ac.uk/pdbsum/4nqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LEUC_METJA LEUC_METJA]] Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.<ref>PMID:17449626</ref>
[https://www.uniprot.org/uniprot/LEUC_METJA LEUC_METJA] Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.<ref>PMID:17449626</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hwang, K Y]]
[[Category: Large Structures]]
[[Category: Lee, E H]]
[[Category: Methanocaldococcus jannaschii DSM 2661]]
[[Category: Lee, K]]
[[Category: Hwang KY]]
[[Category: Alpha-beta sandwitch]]
[[Category: Lee EH]]
[[Category: Cytosol]]
[[Category: Lee K]]
[[Category: Fe-s cluster]]
[[Category: Isomerase]]
[[Category: Lyase]]
[[Category: Mj1277]]

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