4n8v: Difference between revisions

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 ==Crystal structure of killer cell immunoglobulin-like receptor KIR2DS2 in complex with HLA-A==
-<StructureSection load='4n8v' size='340' side='right' caption='[[4n8v]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='4n8v' size='340' side='right'caption='[[4n8v]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4n8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8V FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4n8v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8V FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIR2DS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HLA-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8v OCA], [http://pdbe.org/4n8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n8v RCSB], [http://www.ebi.ac.uk/pdbsum/4n8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8v ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8v OCA], [https://pdbe.org/4n8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8v RCSB], [https://www.ebi.ac.uk/pdbsum/4n8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8v ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/A14_VACCW A14_VACCW]] Envelope protein which is a major component of the mature virion (MV) membrane. Essential for membrane biogenesis. Is required, together with A17, to form bona fide crescents, which can progress to form the immature virion (IV) membrane. A14 and A17 form a lattice that is stabilized by disulfide bonds and serves as an anchor within the viral membrane to which several other proteins important in virion structure and morphogenesis attach.<ref>PMID:9445029</ref> <ref>PMID:10729144</ref>  [[http://www.uniprot.org/uniprot/KI2S2_HUMAN KI2S2_HUMAN]] Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/1A11_HUMAN 1A11_HUMAN]] Involved in the presentation of foreign antigens to the immune system.
+[https://www.uniprot.org/uniprot/KI2S2_HUMAN KI2S2_HUMAN] Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 4n8v" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
+*[[NK cell receptor|NK cell receptor]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Liu, J X]]
+[[Category: Large Structures]]
-[[Category: Ren, E C]]
+[[Category: Vaccinia virus WR]]
-[[Category: Activating kir]]
+[[Category: Liu JX]]
-[[Category: Antigen presentation]]
+[[Category: Ren EC]]
-[[Category: Cell lysing]]
-[[Category: Immune system]]
-[[Category: Kir binding]]
-[[Category: Kir2ds2]]
-[[Category: Membrane]]