4n8v: Difference between revisions
New page: '''Unreleased structure''' The entry 4n8v is ON HOLD Authors: LIU, J.X, REN, E.C Description: Crystal structure of killer cell immunoglobulin-like receptor KIR2DS2 in complex with HLA-... |
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==Crystal structure of killer cell immunoglobulin-like receptor KIR2DS2 in complex with HLA-A== | |||
<StructureSection load='4n8v' size='340' side='right'caption='[[4n8v]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4n8v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8v OCA], [https://pdbe.org/4n8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8v RCSB], [https://www.ebi.ac.uk/pdbsum/4n8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KI2S2_HUMAN KI2S2_HUMAN] Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Inhibitory killer cell Ig-like receptors (KIRs) are known to recognize HLA ligands mainly of the HLA-C and Bw4 groups, but the ligands for KIRs are poorly understood. We report here the identification of the cognate ligand for the activating KIR 2DS2 as HLA-A*11:01. The crystal structure of the KIR2DS2-HLA-A*11:01 complex was solved at 2.5-A resolution and revealed residue-binding characteristics distinct from those of inhibitory KIRs with HLA-C and the critical role of residues Tyr45 and Asp72 in shaping binding specificity to HLA-A*11:01. Using KIR2DS2 tetramers, binding to surface HLA-A*11:01 on live cells was demonstrated and, furthermore, that binding can be altered by residue changes at p8 of the peptide, indicating the influence of peptide sequence on KIR-HLA association. In addition, heteronuclear single quantum coherence NMR was used to map the involvement of critical residues in HLA binding at the interface of KIR and HLA, and validates the data observed in the crystal structure. Our data provide structural evidence of the recognition of A*11:01 by the activating KIR2DS2 and extend our understanding of the KIR-HLA binding spectrum. | |||
Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11.,Liu J, Xiao Z, Ko HL, Shen M, Ren EC Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2662-7. doi:, 10.1073/pnas.1322052111. Epub 2014 Feb 3. PMID:24550293<ref>PMID:24550293</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4n8v" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | |||
*[[NK cell receptor|NK cell receptor]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Vaccinia virus WR]] | |||
[[Category: Liu JX]] | |||
[[Category: Ren EC]] | |||