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==Structure determination of cystathionine gamma-synthase from Helicobacter pylori==
==Structure determination of cystathionine gamma-synthase from Helicobacter pylori==
<StructureSection load='4l0o' size='340' side='right' caption='[[4l0o]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
<StructureSection load='4l0o' size='340' side='right'caption='[[4l0o]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l0o]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L0O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l0o]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L0O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cystathionine gamma-synthase, HP_0106, metB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cystathionine_gamma-synthase Cystathionine gamma-synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.48 2.5.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0o OCA], [https://pdbe.org/4l0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l0o RCSB], [https://www.ebi.ac.uk/pdbsum/4l0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l0o RCSB], [http://www.ebi.ac.uk/pdbsum/4l0o PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/METB_HELPY METB_HELPY]] Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).  
[https://www.uniprot.org/uniprot/METB_HELPY METB_HELPY] Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).
 
==See Also==
*[[Cystathionine gamma synthase|Cystathionine gamma synthase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Campylobacter pylori]]
[[Category: Helicobacter pylori 26695]]
[[Category: Cystathionine gamma-synthase]]
[[Category: Large Structures]]
[[Category: Gourinath, S]]
[[Category: Gourinath S]]
[[Category: Rehman, S A.A]]
[[Category: Rehman SAA]]
[[Category: Tarique, K F]]
[[Category: Tarique KF]]
[[Category: C-s bond cleavage]]
[[Category: Elimination]]
[[Category: Lyase]]

Latest revision as of 17:32, 8 November 2023

Structure determination of cystathionine gamma-synthase from Helicobacter pyloriStructure determination of cystathionine gamma-synthase from Helicobacter pylori

Structural highlights

4l0o is a 8 chain structure with sequence from Helicobacter pylori 26695. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.76Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

METB_HELPY Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).

See Also

4l0o, resolution 2.76Å

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