4iax: Difference between revisions

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 ==Engineered human lipocalin 2 (CL31) in complex with Y-DTPA==
-<StructureSection load='4iax' size='340' side='right' caption='[[4iax]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='4iax' size='340' side='right'caption='[[4iax]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4iax]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IAX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4iax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IAX FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LIZ:N-{(1S,2S)-2-[BIS(CARBOXYMETHYL)AMINO]CYCLOHEXYL}-N-{(2R)-2-[BIS(CARBOXYMETHYL)AMINO]-3-[4-({[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]CARBAMOTHIOYL}AMINO)PHENYL]PROPYL}GLYCINE'>LIZ</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dsz|3dsz]], [[3dtq|3dtq]], [[4iaw|4iaw]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LIZ:N-{(1S,2S)-2-[BIS(CARBOXYMETHYL)AMINO]CYCLOHEXYL}-N-{(2R)-2-[BIS(CARBOXYMETHYL)AMINO]-3-[4-({[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]CARBAMOTHIOYL}AMINO)PHENYL]PROPYL}GLYCINE'>LIZ</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNL, LCN2, NGAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iax OCA], [https://pdbe.org/4iax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iax RCSB], [https://www.ebi.ac.uk/pdbsum/4iax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iax ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iax OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iax RCSB], [http://www.ebi.ac.uk/pdbsum/4iax PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4iax" style="background-color:#fffaf0;"></div>
 ==See Also==
 *[[Neutrophil gelatinase-associated lipocalin|Neutrophil gelatinase-associated lipocalin]]
+*[[Siderocalin 3D structures|Siderocalin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Eichinger, A]]
+[[Category: Large Structures]]
-[[Category: Skerra, A]]
+[[Category: Eichinger A]]
-[[Category: Beta-barrel]]
+[[Category: Skerra A]]
-[[Category: Binding protein]]
-[[Category: Engineered lipocalin]]
-[[Category: Strep-tag]]
-[[Category: Transport protein]]
-[[Category: Y-chx-a''-dtpa]]