4gu1: Difference between revisions

<StructureSection load='4gu1' size='340' side='right' caption='[[4gu1]], [[Resolution|resolution]] 2.94&Aring;' scene=''>

<table><tr><td colspan='2'>[[4gu1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GU1 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LSD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu1 OCA], [http://pdbe.org/4gu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gu1 RCSB], [http://www.ebi.ac.uk/pdbsum/4gu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu1 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/KDM1B_HUMAN KDM1B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity).  

*[[Lysine-specific histone demethylase|Lysine-specific histone demethylase]]

[[Category: Human]]

[[Category: Chen, F]]

[[Category: Dong, Z]]

[[Category: Fang, J]]

[[Category: Fang, R]]

[[Category: Li, Z]]

[[Category: Shi, Y]]

[[Category: Wang, P]]

[[Category: Xu, Y]]

[[Category: Yang, H]]

[[Category: Yang, Y]]

[[Category: Oxidoreductase]]