4fbj: Difference between revisions

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-[[Image:4fbj.jpg|left|200px]]
-{{STRUCTURE_4fbj|  PDB=4fbj  |  SCENE=  }}
+==Structure of the Cif:Nedd8 complex - Photorhabdus luminescens Cycle Inhibiting Factor in complex with human Nedd8==
+<StructureSection load='4fbj' size='340' side='right'caption='[[4fbj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fbj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Photorhabdus_laumondii_subsp._laumondii_TTO1 Photorhabdus laumondii subsp. laumondii TTO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBJ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbj OCA], [https://pdbe.org/4fbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbj RCSB], [https://www.ebi.ac.uk/pdbsum/4fbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CIF_PHOLL CIF_PHOLL] Protein-glutamine deamidase effector that inhibits the host cell cycle and other key cellular processes such as the actin network and programmed-cell death (PubMed:19308257, PubMed:19225106, PubMed:20870031). Acts by mediating the side chain deamidation of 'Gln-40' of host NEDD8, converting it to glutamate, thereby abolishing the activity of cullin-RING-based E3 ubiquitin-protein ligase complexes (CRL complexes) (By similarity). Inactivation of CRL complexes prevents ubiquitination and subsequent degradation of the cyclin-dependent kinase inhibitors CDKN1A/p21 and CDKN1B/p27, leading to G1 and G2 cell cycle arrests in host cells (PubMed:19308257). Deamidation of 'Gln-40' of host NEDD8 also triggers macrophage-specific programmed cell death (By similarity). Also able to catalyze deamidation of 'Gln-40' of host ubiquitin in vitro; however, NEDD8 constitutes the preferred substrate in vivo (By similarity).[UniProtKB:Q63KH5]<ref>PMID:19225106</ref> <ref>PMID:19308257</ref> <ref>PMID:20870031</ref>
-===Structure of the Cif:Nedd8 complex - Photorhabdus luminescens Cycle Inhibiting Factor in complex with human Nedd8===
+==See Also==
+*[[NEDD8|NEDD8]]
+== References ==
-==About this Structure==
+<references/>
-[[4fbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Photorhabdus_luminescens_subsp._laumondii Photorhabdus luminescens subsp. laumondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBJ OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Photorhabdus luminescens subsp. laumondii]]
+[[Category: Large Structures]]
-[[Category: Banfield, M J.]]
+[[Category: Photorhabdus laumondii subsp. laumondii TTO1]]
-[[Category: Crow, A.]]
+[[Category: Banfield MJ]]
-[[Category: Bacterial effector]]
+[[Category: Crow A]]
-[[Category: Cell cycle-protein binding complex]]
-[[Category: Deamidation]]
-[[Category: Effector-host target complex]]
-[[Category: Glutamine deamidase]]