3wql: Difference between revisions

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 ==Crystal structure of Rv3378c with Mg2+ and PPi==
-<StructureSection load='3wql' size='340' side='right' caption='[[3wql]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='3wql' size='340' side='right'caption='[[3wql]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3wql]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WQL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3wql]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wqk|3wqk]], [[3wqm|3wqm]], [[3wqn|3wqn]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv3378c, MT3488 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wql OCA], [https://pdbe.org/3wql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wql RCSB], [https://www.ebi.ac.uk/pdbsum/3wql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wql ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wql RCSB], [http://www.ebi.ac.uk/pdbsum/3wql PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TUBOL_MYCTU TUBOL_MYCTU]] Catalyzes the PP-removal from tuberculosinyl diphosphate to produce both tubercilosinol and isotuberculosinol. Can also use labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro.
+[https://www.uniprot.org/uniprot/TUBAT_MYCTU TUBAT_MYCTU] Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1-tuberculosinyladenosine (1-TbAd), which acts as an antiacid that directly protects M.tuberculosis from acid pH and physically remodels M.tuberculosis phagolysosomes (PubMed:24516143, PubMed:31427817). In addition, acts as a phosphatase that catalyzes the diphosphate-removal from TbPP to produce both tuberculosinol (TOH) and isotuberculosinol (iso-TOH) (PubMed:21228491, PubMed:24475925). Has broad substrate specificity, and can also use the 3 labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro (PubMed:21290071).<ref>PMID:21228491</ref> <ref>PMID:21290071</ref> <ref>PMID:24475925</ref> <ref>PMID:24516143</ref> <ref>PMID:31427817</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3wql" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Bogue, S]]
+[[Category: Large Structures]]
-[[Category: Chan, H C]]
+[[Category: Mycobacterium tuberculosis]]
-[[Category: Crick, D C]]
+[[Category: Bogue S]]
-[[Category: Feng, X]]
+[[Category: Chan HC]]
-[[Category: Guo, R T]]
+[[Category: Crick DC]]
-[[Category: Hoshino, T]]
+[[Category: Feng X]]
-[[Category: Hu, Y]]
+[[Category: Guo RT]]
-[[Category: Huang, C H]]
+[[Category: Hoshino T]]
-[[Category: Ko, T P]]
+[[Category: Hu Y]]
-[[Category: Liang, P H]]
+[[Category: Huang CH]]
-[[Category: Liu, W]]
+[[Category: Ko TP]]
-[[Category: Lv, P]]
+[[Category: Liang PH]]
-[[Category: Nakano, C]]
+[[Category: Liu W]]
-[[Category: Oldfield, E]]
+[[Category: Lv P]]
-[[Category: Wang, A H]]
+[[Category: Nakano C]]
-[[Category: Zhang, L]]
+[[Category: Oldfield E]]
-[[Category: Zheng, Y]]
+[[Category: Wang AH]]
-[[Category: Diterpene synthase]]
+[[Category: Zhang L]]
-[[Category: Hydrolase]]
+[[Category: Zheng Y]]
-[[Category: Phosphatase]]