3whe: Difference between revisions

<table><tr><td colspan='2'>[[3whe]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/aichi/2-1/1968(h3n2)) Influenza a virus (a/aichi/2-1/1968(h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WHE FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">126567434, HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1391655 Influenza A virus (A/Aichi/2-1/1968(H3N2))])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3whe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3whe OCA], [http://pdbe.org/3whe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3whe RCSB], [http://www.ebi.ac.uk/pdbsum/3whe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3whe ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/T2HNI1_9INFA T2HNI1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS000149_004_327643]  

[[Category: Human]]

[[Category: Fujii, Y]]

[[Category: Shirouzu, M]]

[[Category: Sumida, T]]

[[Category: Yokoyama, S]]

[[Category: Viral protein-immune system complex]]