3wg2: Difference between revisions
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==Crystal structure of Agrocybe cylindracea galectin mutant (N46A)== | ==Crystal structure of Agrocybe cylindracea galectin mutant (N46A)== | ||
<StructureSection load='3wg2' size='340' side='right' caption='[[3wg2]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3wg2' size='340' side='right'caption='[[3wg2]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3wg2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3wg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyclocybe_aegerita Cyclocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg2 OCA], [https://pdbe.org/3wg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3wg2" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Galectin 3D structures|Galectin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Cyclocybe aegerita]] | ||
[[Category: Hirabayashi | [[Category: Large Structures]] | ||
[[Category: Hu | [[Category: Hirabayashi J]] | ||
[[Category: Kato | [[Category: Hu D]] | ||
[[Category: Kuwabara | [[Category: Kato R]] | ||
[[Category: Makio | [[Category: Kuwabara N]] | ||
[[Category: Tateno | [[Category: Makio H]] | ||
[[Category: Tateno H]] | |||