3v3e: Difference between revisions

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==Crystal Structure of the Human Nur77 Ligand-binding Domain==
==Crystal Structure of the Human Nur77 Ligand-binding Domain==
<StructureSection load='3v3e' size='340' side='right' caption='[[3v3e]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
<StructureSection load='3v3e' size='340' side='right'caption='[[3v3e]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3E FirstGlance]. <br>
<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v3q|3v3q]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [https://pdbe.org/3v3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [https://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [http://pdbe.org/3v3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [http://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chen, Y]]
[[Category: Large Structures]]
[[Category: Lin, T]]
[[Category: Chen Y]]
[[Category: Shi, C]]
[[Category: Lin T]]
[[Category: Wu, Q]]
[[Category: Shi C]]
[[Category: Yang, K]]
[[Category: Wu Q]]
[[Category: Zhan, Y]]
[[Category: Yang K]]
[[Category: Zhang, Q]]
[[Category: Zhan Y]]
[[Category: Orphan nuclear receptor]]
[[Category: Zhang Q]]
[[Category: Transcription]]

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