3uzc: Difference between revisions

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 ==Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol==
-<StructureSection load='3uzc' size='340' side='right' caption='[[3uzc]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
+<StructureSection load='3uzc' size='340' side='right'caption='[[3uzc]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3uzc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UZC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3uzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UZC FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T4E:4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL'>T4E</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.341&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uza|3uza]], [[3pwh|3pwh]], [[3rfm|3rfm]], [[3rey|3rey]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T4E:4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL'>T4E</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADORA2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzc OCA], [https://pdbe.org/3uzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uzc RCSB], [https://www.ebi.ac.uk/pdbsum/3uzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uzc ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uzc RCSB], [http://www.ebi.ac.uk/pdbsum/3uzc PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 16: @@
 Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design.,Congreve M, Andrews SP, Dore AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH J Med Chem. 2012 Mar 8;55(5):1898-903. Epub 2012 Jan 27. PMID:22220592<ref>PMID:22220592</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3uzc" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Adenosine A2A receptor|Adenosine A2A receptor]]
+*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
 == References ==
 <references/>
@@ Line 24: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Andrews, S P.]]
+[[Category: Large Structures]]
-[[Category: Congreve, M.]]
+[[Category: Andrews SP]]
-[[Category: Dore, A S.]]
+[[Category: Congreve M]]
-[[Category: Hollenstein, K.]]
+[[Category: Dore AS]]
-[[Category: Hurrell, E.]]
+[[Category: Hollenstein K]]
-[[Category: Langmead, C J.]]
+[[Category: Hurrell E]]
-[[Category: Marshall, F H.]]
+[[Category: Langmead CJ]]
-[[Category: Mason, J S.]]
+[[Category: Marshall FH]]
-[[Category: Ng, I W.]]
+[[Category: Mason JS]]
-[[Category: Weir, M.]]
+[[Category: Ng IW]]
-[[Category: Zhukov, A.]]
+[[Category: Weir M]]
-[[Category: 7tm]]
+[[Category: Zhukov A]]
-[[Category: G-protein]]
-[[Category: Gpcr]]
-[[Category: Membrane protein]]
-[[Category: Signaling protein]]