5lzk: Difference between revisions

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New page: '''Unreleased structure''' The entry 5lzk is ON HOLD Authors: Pinkas, D.M., Bufton, J.C., Williams, E.P., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A....
 
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'''Unreleased structure'''


The entry 5lzk is ON HOLD
==Structure of the domain of unknown function DUF1669 from human FAM83B==
 
<StructureSection load='5lzk' size='340' side='right'caption='[[5lzk]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
Authors: Pinkas, D.M., Bufton, J.C., Williams, E.P., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5lzk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LZK FirstGlance]. <br>
Description: Structure of the domain of unknown function DUF1669 from human FAM83B
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.575&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
[[Category: Bullock, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzk OCA], [https://pdbe.org/5lzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lzk RCSB], [https://www.ebi.ac.uk/pdbsum/5lzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzk ProSAT]</span></td></tr>
[[Category: Burgess-Brown, N.A]]
</table>
[[Category: Pinkas, D.M]]
== Function ==
[[Category: Bountra, C]]
[https://www.uniprot.org/uniprot/FA83B_HUMAN FA83B_HUMAN] Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.<ref>PMID:22886302</ref> <ref>PMID:23676467</ref> <ref>PMID:23912460</ref>
[[Category: Williams, E.P]]
== References ==
[[Category: Arrowsmith, C.H]]
<references/>
[[Category: Shrestha, L]]
__TOC__
[[Category: Von Delft, F]]
</StructureSection>
[[Category: Bufton, J.C]]
[[Category: Homo sapiens]]
[[Category: Edwards, A.M]]
[[Category: Large Structures]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bufton JC]]
[[Category: Bullock A]]
[[Category: Burgess-Brown NA]]
[[Category: Edwards AM]]
[[Category: Pinkas DM]]
[[Category: Shrestha L]]
[[Category: Williams EP]]
[[Category: Von Delft F]]

Latest revision as of 21:18, 1 November 2023

Structure of the domain of unknown function DUF1669 from human FAM83BStructure of the domain of unknown function DUF1669 from human FAM83B

Structural highlights

5lzk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.575Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FA83B_HUMAN Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.[1] [2] [3]

References

  1. ↑ Cipriano R, Graham J, Miskimen KL, Bryson BL, Bruntz RC, Scott SA, Brown HA, Stark GR, Jackson MW. FAM83B mediates EGFR- and RAS-driven oncogenic transformation. J Clin Invest. 2012 Sep;122(9):3197-210. doi: 10.1172/JCI60517. Epub 2012 Aug 13. PMID:22886302 doi:http://dx.doi.org/10.1172/JCI60517
  2. ↑ Cipriano R, Miskimen KL, Bryson BL, Foy CR, Bartel CA, Jackson MW. FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Oncotarget. 2013 May;4(5):729-38. PMID:23676467 doi:http://dx.doi.org/10.18632/oncotarget.1027
  3. ↑ Cipriano R, Bryson BL, Miskimen KL, Bartel CA, Hernandez-Sanchez W, Bruntz RC, Scott SA, Lindsley CW, Brown HA, Jackson MW. Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B. Oncogene. 2014 Jun 19;33(25):3298-306. doi: 10.1038/onc.2013.293. Epub 2013 Aug, 5. PMID:23912460 doi:http://dx.doi.org/10.1038/onc.2013.293

5lzk, resolution 1.57Å

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