3t6b: Difference between revisions

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-[[Image:3t6b.jpg|left|200px]]
-<!--
+==Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 2.4 Angstroms==
-The line below this paragraph, containing "STRUCTURE_3t6b", creates the "Structure Box" on the page.
+<StructureSection load='3t6b' size='340' side='right'caption='[[3t6b]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3t6b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T6B FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6b OCA], [https://pdbe.org/3t6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t6b RCSB], [https://www.ebi.ac.uk/pdbsum/3t6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t6b ProSAT]</span></td></tr>
-{{STRUCTURE_3t6b|  PDB=3t6b  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DPP3_HUMAN DPP3_HUMAN] Cleaves Arg-Arg-beta-naphthylamide.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Opioid peptides are involved in various essential physiological processes, most notably nociception. Dipeptidyl peptidase III (DPP III) is one of the most important enkephalin-degrading enzymes associated with the mammalian pain modulatory system. Here we describe the X-ray structures of human DPP III and its complex with the opioid peptide tynorphin, which rationalize the enzyme's substrate specificity and reveal an exceptionally large domain motion upon ligand binding. Microcalorimetric analyses point at an entropy-dominated process, with the release of water molecules from the binding cleft ("entropy reservoir") as the major thermodynamic driving force. Our results provide the basis for the design of specific inhibitors that enable the elucidation of the exact role of DPP III and the exploration of its potential as a target of pain intervention strategies.
-===Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 2.4 Angstroms===
+Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.,Bezerra GA, Dobrovetsky E, Viertlmayr R, Dong A, Binter A, Abramic M, Macheroux P, Dhe-Paganon S, Gruber K Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6525-30. Epub 2012 Apr 9. PMID:22493238<ref>PMID:22493238</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3t6b" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3t6b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6B OCA].
+*[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]]
-[[Category: Dipeptidyl-peptidase III]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bezerra, G A.]]
+[[Category: Large Structures]]
-[[Category: Gruber, K.]]
+[[Category: Bezerra GA]]
-[[Category: Domain motion]]
+[[Category: Gruber K]]
-[[Category: Entropy binding]]
-[[Category: Human dipeptidylpeptidase iii]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Opioid peptide complex]]