3t0c: Difference between revisions

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-[[Image:3t0c.png|left|200px]]
-<!--
+==Crystal structure of Streptococcus mutans MetE complexed with Zinc==
-The line below this paragraph, containing "STRUCTURE_3t0c", creates the "Structure Box" on the page.
+<StructureSection load='3t0c' size='340' side='right'caption='[[3t0c]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3t0c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l7s 3l7s]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T0C FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.187&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3t0c|  PDB=3t0c  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t0c OCA], [https://pdbe.org/3t0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t0c RCSB], [https://www.ebi.ac.uk/pdbsum/3t0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t0c ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/METE_STRMU METE_STRMU] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cobalamin-independent methionine synthase (MetE) catalyzes the direct transfer of a methyl group from methyltetrahydrofolate to l-homocysteine to form methionine. Previous studies have shown that the MetE active site coordinates a zinc atom, which is thought to act as a Lewis acid and plays a role in the activation of thiol. Extended X-ray absorption fine structure studies and mutagenesis experiments identified the zinc-binding site in MetE from Escherichia coli. Further structural investigations of MetE from Thermotoga maritima lead to the proposition of two models: "induced fit" and "dynamic equilibrium", to account for the catalytic mechanisms of MetE. Here, we present crystal structures of oxidized and zinc-replete MetE from Streptococcus mutans at the physiological pH. The structures reveal that zinc is mobile in the active center and has the possibility to invert even in the absence of homocysteine. These structures provide evidence for the dynamic equilibrium model.
-===Crystal structure of Streptococcus mutans MetE complexed with Zinc===
+Crystal Structures of Cobalamin-Independent Methionine Synthase (MetE) from Streptococcus mutans: A Dynamic Zinc-Inversion Model.,Fu TM, Almqvist J, Liang YH, Li L, Huang Y, Su XD J Mol Biol. 2011 Sep 30;412(4):688-97. Epub 2011 Aug 5. PMID:21840320<ref>PMID:21840320</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3t0c" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21840320}}, adds the Publication Abstract to the page
+*[[Methionine synthase 3D structures|Methionine synthase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21840320 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21840320}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[3t0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l7s 3l7s]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0C OCA].
-==Reference==
-<ref group="xtra">PMID:021840320</ref><references group="xtra"/>
-[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
 [[Category: Streptococcus mutans]]
-[[Category: Fu, T M.]]
+[[Category: Fu TM]]
-[[Category: Liang, Y H.]]
+[[Category: Liang YH]]
-[[Category: Su, X D.]]
+[[Category: Su XD]]
-[[Category: Barrel]]
-[[Category: Mete]]
-[[Category: Methyltransferase]]
-[[Category: Transferase]]