3sut: Difference between revisions

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[[Image:3sut.jpg|left|200px]]


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==Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with PUGNAc==
The line below this paragraph, containing "STRUCTURE_3sut", creates the "Structure Box" on the page.
<StructureSection load='3sut' size='340' side='right'caption='[[3sut]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3sut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenibacillus_sp._TS12 Paenibacillus sp. TS12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SUT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OAN:O-(2-ACETAMIDO-2-DEOXY+D-GLUCOPYRANOSYLIDENE)+AMINO-N-PHENYLCARBAMATE'>OAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3sut|  PDB=3sut  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sut OCA], [https://pdbe.org/3sut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sut RCSB], [https://www.ebi.ac.uk/pdbsum/3sut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sut ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D2KW09_9BACL D2KW09_9BACL]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-beta-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-beta-N-acetylhexosaminidases but also other types of glycoside hydrolases.


===Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with PUGNAc===
Gaining insight into the inhibition of glycoside hydrolase family 20 exo-beta-N-acetylhexosaminidases using a structural approach.,Sumida T, Stubbs KA, Ito M, Yokoyama S Org Biomol Chem. 2012 Apr 7;10(13):2607-12. Epub 2012 Feb 27. PMID:22367352<ref>PMID:22367352</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3sut" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_22367352}}, adds the Publication Abstract to the page
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
(as it appears on PubMed at http://www.pubmed.gov), where 22367352 is the PubMed ID number.
*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
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*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
{{ABSTRACT_PUBMED_22367352}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3sut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paenibacillus Paenibacillus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUT OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
[[Category: Paenibacillus sp. TS12]]
<ref group="xtra">PMID:022367352</ref><references group="xtra"/>
[[Category: Sumida T]]
[[Category: Beta-N-acetylhexosaminidase]]
[[Category: Yokoyama S]]
[[Category: Paenibacillus]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sumida, T.]]
[[Category: Yokoyama, S.]]
[[Category: Carbohydrate/sugar binding]]
[[Category: Hydrolase]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Tim barrel]]

Latest revision as of 20:26, 1 November 2023

Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with PUGNAcCrystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with PUGNAc

Structural highlights

3sut is a 1 chain structure with sequence from Paenibacillus sp. TS12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

D2KW09_9BACL

Publication Abstract from PubMed

One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-beta-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-beta-N-acetylhexosaminidases but also other types of glycoside hydrolases.

Gaining insight into the inhibition of glycoside hydrolase family 20 exo-beta-N-acetylhexosaminidases using a structural approach.,Sumida T, Stubbs KA, Ito M, Yokoyama S Org Biomol Chem. 2012 Apr 7;10(13):2607-12. Epub 2012 Feb 27. PMID:22367352[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Sumida T, Stubbs KA, Ito M, Yokoyama S. Gaining insight into the inhibition of glycoside hydrolase family 20 exo-beta-N-acetylhexosaminidases using a structural approach. Org Biomol Chem. 2012 Apr 7;10(13):2607-12. Epub 2012 Feb 27. PMID:22367352 doi:10.1039/c2ob06636j

3sut, resolution 1.90Å

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