3qlm: Difference between revisions

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-[[Image:3qlm.jpg|left|200px]]
-<!--
+==Crystal structure of porcine pancreatic phospholipase A2 in complex with n-hexadecanoic acid==
-The line below this paragraph, containing "STRUCTURE_3qlm", creates the "Structure Box" on the page.
+<StructureSection load='3qlm' size='340' side='right'caption='[[3qlm]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3qlm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-{{STRUCTURE_3qlm|  PDB=3qlm  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlm OCA], [https://pdbe.org/3qlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlm RCSB], [https://www.ebi.ac.uk/pdbsum/3qlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ester bond hydrolysis of membrane phospholipids by Phospholipase A(2) and consequent release of fatty acids is the initiating step of inflammation. It is proposed here that the inhibition of PLA(2) is one of the ways to control inflammation. Investigations are done to identify the mode of inhibition of PLA(2) by the n-hexadecanoic acid. It may help designing of specific inhibitors of PLA(2) as anti-inflammatory agents. The enzyme kinetics study proved that n-hexadecanoic acid inhibits PLA(2) in a competitive manner. It was identified from the crystal structure at 2.5A resolution that the position of n-hexadecanoic acid is in the active site of the PLA(2) . The binding constant and binding energy have also been calculated using Isothermal Titration Calorimetry. Also, the binding energy of n-hexadecanoic acid to PLA(2) was calculated by in silico method and compared with known inhibitors. It may be concluded from the structural and kinetics studies that the fatty acid, n-hexadecanoic acid, is an inhibitor of PLA(2) . The inferences from the present study validate the rigorous use of medicated oils rich in n-hexadecanoic acid for the treatment of rheumatic symptoms in the traditional medical system of India, Ayurveda. (c) 2012 John Wiley &amp; Sons A/S.
-===Crystal structure of porcine pancreatic phospholipase A2 in complex with n-hexadecanoic acid===
+Anti-inflammatory property of n-hexadecanoic acid: Structural evidence and Kinetic assessment.,Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M Chem Biol Drug Des. 2012 May 29. doi: 10.1111/j.1747-0285.2012.01418.x. PMID:22642495<ref>PMID:22642495</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3qlm" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3qlm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLM OCA].
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Sus scrofa]]
-[[Category: Aparna, V.]]
+[[Category: Aparna V]]
-[[Category: Dileep, K V.]]
+[[Category: Dileep KV]]
-[[Category: Haridas, M.]]
+[[Category: Haridas M]]
-[[Category: Karthe, P.]]
+[[Category: Karthe P]]
-[[Category: Mandal, P K.]]
+[[Category: Mandal PK]]
-[[Category: Sadasivan, C.]]
+[[Category: Sadasivan C]]