3q2c: Difference between revisions
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==Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e)== | ==Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e)== | ||
<StructureSection load='3q2c' size='340' side='right' caption='[[3q2c]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3q2c' size='340' side='right'caption='[[3q2c]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3q2c]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3q2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2c OCA], [https://pdbe.org/3q2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2c RCSB], [https://www.ebi.ac.uk/pdbsum/3q2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/LIRA3_HUMAN LIRA3_HUMAN] Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.<ref>PMID:21559424</ref> <ref>PMID:24085305</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3q2c" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3q2c" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Cheng | [[Category: Chen Y]] | ||
[[Category: Gao | [[Category: Cheng H]] | ||
[[Category: Liu | [[Category: Gao GF]] | ||
[[Category: Qi | [[Category: Liu J]] | ||
[[Category: Ryu | [[Category: Qi JX]] | ||
[[Category: Shi | [[Category: Ryu M]] | ||
[[Category: Shi Y]] | |||