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==Crystal structure of the MUNC18-1 and SYNTAXIN4 N-Peptide complex==
==Crystal structure of the MUNC18-1 and SYNTAXIN4 N-Peptide complex==
<StructureSection load='3puj' size='340' side='right' caption='[[3puj]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
<StructureSection load='3puj' size='340' side='right'caption='[[3puj]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3puj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PUJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3puj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUJ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stxbp1, Unc18a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.313&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3puj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3puj OCA], [http://pdbe.org/3puj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3puj RCSB], [http://www.ebi.ac.uk/pdbsum/3puj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3puj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3puj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3puj OCA], [https://pdbe.org/3puj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3puj RCSB], [https://www.ebi.ac.uk/pdbsum/3puj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3puj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STXB1_RAT STXB1_RAT]] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. [[http://www.uniprot.org/uniprot/STX4_MOUSE STX4_MOUSE]] Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.<ref>PMID:9045631</ref> <ref>PMID:10394363</ref> <ref>PMID:18827011</ref> 
[https://www.uniprot.org/uniprot/STXB1_RAT STXB1_RAT] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3puj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3puj" style="background-color:#fffaf0;"></div>
==See Also==
*[[Syntaxin-binding protein|Syntaxin-binding protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Christie, M P]]
[[Category: Mus musculus]]
[[Category: Collins, B M]]
[[Category: Rattus norvegicus]]
[[Category: Hu, S H]]
[[Category: Christie MP]]
[[Category: Jarrott, R]]
[[Category: Collins BM]]
[[Category: Latham, C F]]
[[Category: Hu S-H]]
[[Category: Lua, L H.L]]
[[Category: Jarrott R]]
[[Category: Martin, J L]]
[[Category: Latham CF]]
[[Category: Saez, N J]]
[[Category: Lua LHL]]
[[Category: Endocytosis-exocytosis complex]]
[[Category: Martin JL]]
[[Category: Membrane trafficking]]
[[Category: Saez NJ]]
[[Category: Sm protein]]
[[Category: Snare protein]]
[[Category: Syntaxin]]
[[Category: Syntaxin binding protein]]

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