3nr2: Difference between revisions

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-{{Seed}}
-[[Image:3nr2.jpg|left|200px]]
-<!--
+==Crystal structure of Caspase-6 zymogen==
-The line below this paragraph, containing "STRUCTURE_3nr2", creates the "Structure Box" on the page.
+<StructureSection load='3nr2' size='340' side='right'caption='[[3nr2]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3nr2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NR2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr2 OCA], [https://pdbe.org/3nr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nr2 ProSAT]</span></td></tr>
-{{STRUCTURE_3nr2|  PDB=3nr2  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Dimeric effectors caspase 3 and caspase 7 are activated by initiator caspase processing. In this study, we report the crystal structures of effector caspase 6 (CASP6) zymogen and N-Acetyl-Val-Glu-Ile-Asp-al-inhibited CASP6. Both of these forms of CASP6 have a dimeric structure, and in CASP6 zymogen the intersubunit cleavage site (190)TEVD(193) is well structured and inserts into the active site. This positions residue Asp 193 to be easily attacked by the catalytic residue Cys 163. We demonstrate biochemically that intramolecular cleavage at Asp 193 is a prerequisite for CASP6 self-activation and that this activation mechanism is dependent on the length of the L2 loop. Our results indicate that CASP6 can be activated and regulated through intramolecular self-cleavage.
-===Crystal structure of Caspase-6 zymogen===
+Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation.,Wang XJ, Cao Q, Liu X, Wang KT, Mi W, Zhang Y, Li LF, Leblanc AC, Su XD EMBO Rep. 2010 Oct 1. PMID:20890311<ref>PMID:20890311</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3nr2" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20890311}}, adds the Publication Abstract to the page
+*[[Caspase 3D structures|Caspase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20890311 is the PubMed ID number.
+*[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]]
--->
+*[[Molecular Playground/Caspase-6 and neurodegeneration|Molecular Playground/Caspase-6 and neurodegeneration]]
-{{ABSTRACT_PUBMED_20890311}}
+*[[User:Kevin Buadlart Dagbay|User:Kevin Buadlart Dagbay]]
+== References ==
-==About this Structure==
+<references/>
-NR2 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR2 OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:20890311</ref><references group="xtra"/>
-[[Category: Caspase-6]]
 [[Category: Homo sapiens]]
-[[Category: Liu, X.]]
+[[Category: Large Structures]]
-[[Category: Mi, W.]]
+[[Category: Liu X]]
-[[Category: Su, X D.]]
+[[Category: Mi W]]
-[[Category: Wang, K T.]]
+[[Category: Su X-D]]
-[[Category: Wang, X J.]]
+[[Category: Wang K-T]]
-[[Category: Caspase domain]]
+[[Category: Wang X-J]]
-[[Category: Cysteine protease]]
-[[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:13:48 2010''