3n8f: Difference between revisions

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[[Image:3n8f.png|left|200px]]


{{STRUCTURE_3n8f|  PDB=3n8f  |  SCENE=  }}
==Crystal structure of the complex of goat lactoperoxidase with thiocyanate at 3.2 A resolution==
 
<StructureSection load='3n8f' size='340' side='right'caption='[[3n8f]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
===Crystal structure of the complex of goat lactoperoxidase with thiocyanate at 3.2 A resolution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3n8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N8F FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
[[3n8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8F OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n8f OCA], [https://pdbe.org/3n8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n8f RCSB], [https://www.ebi.ac.uk/pdbsum/3n8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n8f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/3n8f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n8f ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Lactoperoxidase|Lactoperoxidase]]
*[[Lactoperoxidase|Lactoperoxidase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Capra hircus]]
[[Category: Capra hircus]]
[[Category: Peroxidase]]
[[Category: Large Structures]]
[[Category: Kaur, P.]]
[[Category: Kaur P]]
[[Category: Sharma, S.]]
[[Category: Sharma S]]
[[Category: Singh, A K.]]
[[Category: Singh AK]]
[[Category: Singh, R P.]]
[[Category: Singh RP]]
[[Category: Singh, T P.]]
[[Category: Singh TP]]
[[Category: Sinha, M.]]
[[Category: Sinha M]]
[[Category: Vikram, G.]]
[[Category: Vikram G]]
[[Category: Complex]]
[[Category: Lactoperoxidase]]
[[Category: Metal binding protein]]
[[Category: Milk protein]]
[[Category: Nitrate]]
[[Category: Oxidoreductase]]
[[Category: Thiocyanate]]

Latest revision as of 19:44, 1 November 2023

Crystal structure of the complex of goat lactoperoxidase with thiocyanate at 3.2 A resolutionCrystal structure of the complex of goat lactoperoxidase with thiocyanate at 3.2 A resolution

Structural highlights

3n8f is a 2 chain structure with sequence from Capra hircus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.25Å
Ligands:, , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_CAPHI Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Benoy MJ, Essy AK, Sreekumar B, Haridas M. Thiocyanate mediated antifungal and antibacterial property of goat milk lactoperoxidase. Life Sci. 2000;66(25):2433-9. doi: 10.1016/s0024-3205(00)80003-x. PMID:10894086 doi:http://dx.doi.org/10.1016/s0024-3205(00)80003-x

3n8f, resolution 3.25Å

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