3mvg: Difference between revisions

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==Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A==
==Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A==
<StructureSection load='3mvg' size='340' side='right' caption='[[3mvg]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='3mvg' size='340' side='right'caption='[[3mvg]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mvg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Iris_hollandica Iris hollandica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MVG FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mvg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Iris_x_hollandica Iris x hollandica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MVG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b7u|2b7u]], [[1bry|1bry]], [[1ahc|1ahc]], [[1nio|1nio]], [[1rl0|1rl0]], [[2oqa|2oqa]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mvg OCA], [https://pdbe.org/3mvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mvg RCSB], [https://www.ebi.ac.uk/pdbsum/3mvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mvg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mvg OCA], [http://pdbe.org/3mvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mvg RCSB], [http://www.ebi.ac.uk/pdbsum/3mvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mvg ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/O04358_IRIHO O04358_IRIHO]
The most abundant protein of Iris bulbs has been identified as a type 1 ribosome-inactivating protein (RIP). Analysis of the purified proteins and molecular cloning of the corresponding cDNAs demonstrated that this type 1 RIP is a mixture of three isoforms that exhibit a high degree of sequence identity and have similar, though not identical, ribosome-inactivating and polynucleotide:adenosine glycosidase activities. The accumulation of large quantities of type 1 RIP in a vegetative storage organ suggests that this presumed defence-related protein also plays a role in the nitrogen-storage metabolism of the bulb.


Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: characterization and molecular cloning.,Van Damme EJ, Barre A, Barbieri L, Valbonesi P, Rouge P, Van Leuven F, Stirpe F, Peumans WJ Biochem J. 1997 Jun 15;324 ( Pt 3):963-70. PMID:9210423<ref>PMID:9210423</ref>
==See Also==
 
*[[Ribosome inactivating protein 3D structures|Ribosome inactivating protein 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3mvg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Iris hollandica]]
[[Category: Iris x hollandica]]
[[Category: RRNA N-glycosylase]]
[[Category: Large Structures]]
[[Category: Betzel, C]]
[[Category: Betzel C]]
[[Category: Meyer, A]]
[[Category: Meyer A]]
[[Category: Singh, T P]]
[[Category: Singh TP]]
[[Category: Weber, W]]
[[Category: Weber W]]
[[Category: Hydrolase]]
[[Category: Irip]]
[[Category: Pi-loop]]
[[Category: Ribosome inactivating protein type i]]

Latest revision as of 19:40, 1 November 2023

Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 ANative structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A

Structural highlights

3mvg is a 2 chain structure with sequence from Iris x hollandica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.25Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O04358_IRIHO

See Also

3mvg, resolution 1.25Å

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