3ml5: Difference between revisions

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-[[Image:3ml5.jpg|left|200px]]
-<!--
+==Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide==
-The line below this paragraph, containing "STRUCTURE_3ml5", creates the "Structure Box" on the page.
+<StructureSection load='3ml5' size='340' side='right'caption='[[3ml5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ml5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ML5 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3ml5|  PDB=3ml5  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ml5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ml5 OCA], [https://pdbe.org/3ml5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ml5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ml5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ml5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CAH7_HUMAN CAH7_HUMAN] Reversible hydration of carbon dioxide.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Human carbonic anhydrase VII (hCA VII) is a cytosolic member of the alpha-CA family. This enzyme is mainly localized in a number of brain tissues such as the cortex, hippocampus and thalamus and has been noted for its contribution in generating neuronal excitation and seizures. Recently, it has been also proposed that hCA VII may be involved in the control of neuropathic pain, thus its inhibition may offer a new approach in designing pain killers useful for combating neuropathic pain. We report here the X-ray crystallographic structure of a mutated form of human CA VII in complex with acetazolamide, a classical sulfonamide inhibitor. These crystallographic studies provide important implications for the rational drug design of selective CA inhibitors with clinical applications.
-===Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide===
+Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide.,Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G Bioorg Med Chem Lett. 2010 Sep 1;20(17):5023-6. Epub 2010 Jul 16. PMID:20688517<ref>PMID:20688517</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ml5" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20688517}}, adds the Publication Abstract to the page
+*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20688517 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20688517}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[3ml5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML5 OCA].
-==Reference==
-<ref group="xtra">PMID:20688517</ref><references group="xtra"/>
-[[Category: Carbonate dehydratase]]
 [[Category: Homo sapiens]]
-[[Category: Alterio, V.]]
+[[Category: Large Structures]]
-[[Category: Bootorabi, F.]]
+[[Category: Alterio V]]
-[[Category: Dathan, N.]]
+[[Category: Bootorabi F]]
-[[Category: Fiore, A Di.]]
+[[Category: Dathan N]]
-[[Category: Monti, S M.]]
+[[Category: De Simone G]]
-[[Category: Parkkila, S.]]
+[[Category: Di Fiore A]]
-[[Category: Simone, G De.]]
+[[Category: Monti SM]]
-[[Category: Supuran, C T.]]
+[[Category: Parkkila S]]
-[[Category: Truppo, E.]]
+[[Category: Supuran CT]]
+[[Category: Truppo E]]