3lkx: Difference between revisions

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-{{Seed}}
-[[Image:3lkx.jpg|left|200px]]
-<!--
+==Human nac dimerization domain==
-The line below this paragraph, containing "STRUCTURE_3lkx", creates the "Structure Box" on the page.
+<StructureSection load='3lkx' size='340' side='right'caption='[[3lkx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3lkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LKX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkx OCA], [https://pdbe.org/3lkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lkx RCSB], [https://www.ebi.ac.uk/pdbsum/3lkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lkx ProSAT]</span></td></tr>
-{{STRUCTURE_3lkx|  PDB=3lkx  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lkx ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In archaea and eukaryotes, the nascent polypeptide-associated complex (NAC) is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes. The eukaryotic NAC is a heterodimer, and its two subunits form a stable complex through a dimerizing domain called the NAC domain. In addition to acting as a protein translation chaperone, the NAC subunits also function individually in transcriptional regulation. Here we report the crystal structure of the human NAC domain, which reveals the manner of human NAC dimerization. On the basis of the structure, we identified a region in the NAC domain of the human NAC alpha-subunit as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit.
-===Human nac dimerization domain===
+The Crystal Structure of the Human Nascent Polypeptide-Associated Complex Domain Reveals a Nucleic Acid-Binding Region on the NACA Subunit .,Liu Y, Hu Y, Li X, Niu L, Teng M Biochemistry. 2010 Mar 16. PMID:20214399<ref>PMID:20214399</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3lkx" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20214399}}, adds the Publication Abstract to the page
+*[[NAC transcription factor|NAC transcription factor]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20214399 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20214399}}
+__TOC__
+</StructureSection>
-==About this Structure==
-LKX is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA].
-==Reference==
-<ref group="xtra">PMID:20214399</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Hu, Y.]]
+[[Category: Large Structures]]
-[[Category: Li, X.]]
+[[Category: Hu Y]]
-[[Category: Liu, Y.]]
+[[Category: Li X]]
-[[Category: Niu, L.]]
+[[Category: Liu Y]]
-[[Category: Teng, M.]]
+[[Category: Niu L]]
-[[Category: Beta-barrel]]
+[[Category: Teng M]]
-[[Category: Chaperone]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:53:16 2010''