3ko1: Difference between revisions

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-{{Seed}}
-[[Image:3ko1.jpg|left|200px]]
-<!--
+==Cystal structure of thermosome from Acidianus tengchongensis strain S5==
-The line below this paragraph, containing "STRUCTURE_3ko1", creates the "Structure Box" on the page.
+<StructureSection load='3ko1' size='340' side='right'caption='[[3ko1]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ko1]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_tengchongensis Acidianus tengchongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KO1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-{{STRUCTURE_3ko1|  PDB=3ko1  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ko1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ko1 OCA], [https://pdbe.org/3ko1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ko1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ko1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ko1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q877H2_9CREN Q877H2_9CREN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Thermosomes are group II chaperonins responsible for protein refolding in an ATP-dependent manner. Little is known regarding the conformational changes of thermosomes during their functional cycle due to a lack of high-resolution structure in the open state. Here, we report the first complete crystal structure of thermosome (rATcpnbeta) in the open state from Acidianus tengchongensis. There is a approximately 30 degrees rotation of the apical and lid domains compared with the previous closed structure. Besides, the structure reveals a conspicuous hydrophobic patch in the lid domain, and residues locating in this patch are conserved across species. Both the closed and open forms of rATcpnbeta were also reconstructed by electron microscopy (EM). Structural fitting revealed the detailed conformational change from the open to the closed state. Structural comparison as well as protease K digestion indicated only ATP binding without hydrolysis does not induce chamber closure of thermosome.
-===Cystal structure of thermosome from Acidianus tengchongensis strain S5===
+Crystal structure of group II chaperonin in the open state.,Huo Y, Hu Z, Zhang K, Wang L, Zhai Y, Zhou Q, Lander G, Zhu J, He Y, Pang X, Xu W, Bartlam M, Dong Z, Sun F Structure. 2010 Oct 13;18(10):1270-9. PMID:20947016<ref>PMID:20947016</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ko1" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20947016}}, adds the Publication Abstract to the page
+*[[Chaperonin 3D structures|Chaperonin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20947016 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20947016}}
+__TOC__
+</StructureSection>
-==About this Structure==
-KO1 is a 9 chains structure with sequences from [http://en.wikipedia.org/wiki/Acidianus_tengchongensis Acidianus tengchongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO1 OCA].
-==Reference==
-<ref group="xtra">PMID:20947016</ref><references group="xtra"/>
 [[Category: Acidianus tengchongensis]]
-[[Category: Dong, Z.]]
+[[Category: Large Structures]]
-[[Category: He, Y.]]
+[[Category: Dong Z]]
-[[Category: Hu, Z.]]
+[[Category: He Y]]
-[[Category: Huo, Y.]]
+[[Category: Hu Z]]
-[[Category: Lander, G.]]
+[[Category: Huo Y]]
-[[Category: Sun, F.]]
+[[Category: Lander G]]
-[[Category: Wang, L.]]
+[[Category: Sun F]]
-[[Category: Xu, W.]]
+[[Category: Wang L]]
-[[Category: Zhai, Y.]]
+[[Category: Xu W]]
-[[Category: Zhang, K.]]
+[[Category: Zhai Y]]
-[[Category: Zhou, Q.]]
+[[Category: Zhang K]]
-[[Category: Zhu, J.]]
+[[Category: Zhou Q]]
-[[Category: 9-fold symmetry]]
+[[Category: Zhu J]]
-[[Category: Atp hydrolase]]
-[[Category: Chaperone]]
-[[Category: Double ring]]
-[[Category: Nucleotide-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:09:06 2010''