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==Crystal structure of the SdCen/skMLCK complex==
==Crystal structure of the SdCen/skMLCK complex==
<StructureSection load='3kf9' size='340' side='right' caption='[[3kf9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3kf9' size='340' side='right'caption='[[3kf9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3kf9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_dubia Chlamydomonas dubia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KF9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3kf9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Scherffelia_dubia Scherffelia dubia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KF9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kf9 OCA], [http://pdbe.org/3kf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kf9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kf9 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kf9 OCA], [https://pdbe.org/3kf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kf9 RCSB], [https://www.ebi.ac.uk/pdbsum/3kf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kf9 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Familial isolated hypertrophic cardiomyopathy. Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:[http://omim.org/entry/192600 192600]]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11733062</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CATR_SCHDU CATR_SCHDU]] This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell). In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes. [[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.<ref>PMID:11733062</ref> 
[https://www.uniprot.org/uniprot/CATR_SCHDU CATR_SCHDU] This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell). In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes.
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chlamydomonas dubia]]
[[Category: Homo sapiens]]
[[Category: Assairi, L]]
[[Category: Large Structures]]
[[Category: Blouquit, Y]]
[[Category: Scherffelia dubia]]
[[Category: Charbonnier, J B]]
[[Category: Assairi L]]
[[Category: Craescu, C T]]
[[Category: Blouquit Y]]
[[Category: Durand, D]]
[[Category: Charbonnier JB]]
[[Category: Miron, S]]
[[Category: Craescu CT]]
[[Category: Radu, L]]
[[Category: Durand D]]
[[Category: Calmodulin-binding]]
[[Category: Miron S]]
[[Category: Cell cycle]]
[[Category: Radu L]]
[[Category: Cell cycle-calcium-binding protein complex]]
[[Category: Cell division]]
[[Category: Centrin]]
[[Category: Mitosis]]
[[Category: Myosin light chain kinase]]

Latest revision as of 19:12, 1 November 2023

Crystal structure of the SdCen/skMLCK complexCrystal structure of the SdCen/skMLCK complex

Structural highlights

3kf9 is a 4 chain structure with sequence from Homo sapiens and Scherffelia dubia. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CATR_SCHDU This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell). In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes.

3kf9, resolution 2.60Å

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