3isq: Difference between revisions

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-{{Seed}}
-[[Image:3isq.jpg|left|200px]]
-<!--
+==Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase==
-The line below this paragraph, containing "STRUCTURE_3isq", creates the "Structure Box" on the page.
+<StructureSection load='3isq' size='340' side='right'caption='[[3isq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3isq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-{{STRUCTURE_3isq|  PDB=3isq  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isq OCA], [https://pdbe.org/3isq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isq RCSB], [https://www.ebi.ac.uk/pdbsum/3isq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isq ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/HPPD_HUMAN HPPD_HUMAN] Defects in HPD are the cause of tyrosinemia type 3 (TYRO3) [MIM:[https://omim.org/entry/276710 276710]. TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation.<ref>PMID:10942115</ref> <ref>PMID:11073718</ref>   Defects in HPD are a cause of hawkinsinuria (HAWK) [MIM:[https://omim.org/entry/140350 140350]. HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine.<ref>PMID:11073718</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/HPPD_HUMAN HPPD_HUMAN] Key enzyme in the degradation of tyrosine.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3isq ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase===
+==See Also==
+*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
+== References ==
-==Disease==
+<references/>
-Known disease associated with this structure: Hawkinsinuria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609695 609695]], Tyrosinemia, type III OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609695 609695]]
+__TOC__
+</StructureSection>
-==About this Structure==
-ISQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISQ OCA].
-[[Category: 4-hydroxyphenylpyruvate dioxygenase]]
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bountra, C.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bray, J E.]]
+[[Category: Bountra C]]
-[[Category: Cocking, R.]]
+[[Category: Bray JE]]
-[[Category: Delft, F von.]]
+[[Category: Cocking R]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Kavanagh, K L.]]
+[[Category: Kavanagh KL]]
-[[Category: Krojer, T.]]
+[[Category: Krojer T]]
-[[Category: Oppermann, U.]]
+[[Category: Oppermann U]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike ACW]]
-[[Category: Pilka, E S.]]
+[[Category: Pilka ES]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Shafqat N]]
-[[Category: Shafqat, N.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Yue WW]]
-[[Category: Yue, W W.]]
+[[Category: Von Delft F]]
-[[Category: Acetylation]]
-[[Category: Dioxygenase]]
-[[Category: Disease mutation]]
-[[Category: Hydroxyphenylpyruvate]]
-[[Category: Iron]]
-[[Category: Mental retardation]]
-[[Category: Metal-binding]]
-[[Category: Oxidoreductase]]
-[[Category: Phenylalanine catabolism]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Tyrosine catabolism]]
-[[Category: Tyrosine metabolism]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 09:14:05 2009''