3if9: Difference between revisions
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<StructureSection load='3if9' size='340' side='right'caption='[[3if9]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='3if9' size='340' side='right'caption='[[3if9]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3if9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3if9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IF9 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene></td></tr> | |||
<tr id=' | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3if9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3if9 OCA], [https://pdbe.org/3if9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3if9 RCSB], [https://www.ebi.ac.uk/pdbsum/3if9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3if9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3if9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3if9 OCA], [https://pdbe.org/3if9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3if9 RCSB], [https://www.ebi.ac.uk/pdbsum/3if9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3if9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/GLYOX_BACSU GLYOX_BACSU] Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine (PubMed:9827558, PubMed:11744710, PubMed:19864430). Can also oxidize the herbicide glyphosate (N-phosphonomethylglycine) (PubMed:19864430). Displays lower activities on D-alanine, D-valine, D-proline and D-methionine (PubMed:9827558, PubMed:11744710). Does not act on L-amino acids and other D-amino acids (PubMed:9827558). Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (PubMed:12627963).<ref>PMID:11744710</ref> <ref>PMID:12627963</ref> <ref>PMID:19864430</ref> <ref>PMID:9827558</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bacillus subtilis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Molla | [[Category: Molla G]] | ||
[[Category: Moschetti | [[Category: Moschetti T]] | ||
[[Category: Pedotti | [[Category: Pedotti M]] | ||
[[Category: Pollegioni | [[Category: Pollegioni L]] | ||
[[Category: Rosini | [[Category: Rosini E]] | ||
[[Category: Savino | [[Category: Savino C]] | ||
[[Category: Vallone | [[Category: Vallone B]] | ||