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==Crystal structures of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP and Oxalate==
==Crystal structures of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP and Oxalate==
<StructureSection load='3hqo' size='340' side='right' caption='[[3hqo]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='3hqo' size='340' side='right'caption='[[3hqo]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hqo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HQO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hqo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e0v|3e0v]], [[3e0w|3e0w]], [[1pkl|1pkl]], [[3hqn|3hqn]], [[3hqp|3hqp]], [[3hqq|3hqq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 LEIME])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqo OCA], [https://pdbe.org/3hqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hqo RCSB], [https://www.ebi.ac.uk/pdbsum/3hqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqo ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqo OCA], [http://pdbe.org/3hqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hqo RCSB], [http://www.ebi.ac.uk/pdbsum/3hqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KPYK_LEIME KPYK_LEIME]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Pyruvate Kinase|Pyruvate Kinase]]
*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Leime]]
[[Category: Large Structures]]
[[Category: Pyruvate kinase]]
[[Category: Leishmania mexicana]]
[[Category: Morgan, H P]]
[[Category: Morgan HP]]
[[Category: Walkinshaw, M D]]
[[Category: Walkinshaw MD]]
[[Category: Allosteric enzyme]]
[[Category: Glycolysis]]
[[Category: Kinase]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Pyruvate]]
[[Category: R-state enzyme]]
[[Category: Tim barrel]]
[[Category: Transferase]]

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