3hbt: Difference between revisions

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-[[Image:3hbt.png|left|200px]]
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+==The structure of native G-actin==
-The line below this paragraph, containing "STRUCTURE_3hbt", creates the "Structure Box" on the page.
+<StructureSection load='3hbt' size='340' side='right'caption='[[3hbt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3hbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HBT FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3hbt|  PDB=3hbt  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbt OCA], [https://pdbe.org/3hbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hbt RCSB], [https://www.ebi.ac.uk/pdbsum/3hbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hbt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Heat shock proteins act as cytoplasmic chaperones to ensure correct protein folding and prevent protein aggregation. The presence of stoichiometric amounts of one such heat shock protein, Hsp27, in supersaturated solutions of unmodified G-actin leads to crystallization, in preference to polymerization, of the actin. Hsp27 is not evident in the resulting crystal structure. Thus, for the first time, we present the structure of G-actin in a form that is devoid of polymerization-deterring chemical modifications or binding partners, either of which may alter its conformation. The structure contains a calcium ion and ATP within a closed nucleotide-binding cleft, and the D-loop is disordered. This native G-actin structure invites comparison with the current F-actin model in order to understand the structural implications for actin polymerization. In particular, this analysis suggests a mechanism by which the bound cation coordinates conformational change and ATP-hydrolysis.
-===The structure of native G-actin===
+The structure of native G-actin.,Wang H, Robinson RC, Burtnick LD Cytoskeleton (Hoboken). 2010 Jul;67(7):456-65. PMID:20540085<ref>PMID:20540085</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_20540085}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3hbt" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 20540085 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20540085}}
-==About this Structure==
-[[3hbt]] is a 1 chain structure of [[Actin]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBT OCA].
 ==See Also==
-*[[Actin]]
+*[[Actin|Actin]]
+*[[Actin 3D structures|Actin 3D structures]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:20540085</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Oryctolagus cuniculus]]
-[[Category: Burtnick, L D.]]
+[[Category: Burtnick LD]]
-[[Category: Robinson, R C.]]
+[[Category: Robinson RC]]
-[[Category: Wang, H.]]
+[[Category: Wang H]]
-[[Category: Atp-binding]]
-[[Category: Contractile protein]]
-[[Category: Cytoskeleton]]
-[[Category: G-actin]]
-[[Category: Methylation]]
-[[Category: Muscle protein]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]