3dti: Difference between revisions
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==Crystal structure of the IRRE protein, a central regulator of DNA damage repair in deinococcaceae== | ==Crystal structure of the IRRE protein, a central regulator of DNA damage repair in deinococcaceae== | ||
<StructureSection load='3dti' size='340' side='right' caption='[[3dti]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='3dti' size='340' side='right'caption='[[3dti]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3dti]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3dti]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_deserti Deinococcus deserti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DTI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dti OCA], [https://pdbe.org/3dti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dti RCSB], [https://www.ebi.ac.uk/pdbsum/3dti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dti ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IRRE_DEIDV IRRE_DEIDV] Plays a central regulatory role in DNA repair and protection pathways in response to radiation stress. Acts as a site-specific metalloprotease that cleaves and inactivates the repressor proteins DdrOC and DdrOP3, resulting in induced expression of genes required for DNA repair and cell survival after exposure to radiation.<ref>PMID:25170972</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Deinococcus deserti]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: De Groot A]] | ||
[[Category: | [[Category: Dulermo R]] | ||
[[Category: Serre | [[Category: Le Gorrec M]] | ||
[[Category: Servant | [[Category: Serre L]] | ||
[[Category: Sommer | [[Category: Servant P]] | ||
[[Category: Vannier | [[Category: Sommer S]] | ||
[[Category: Vujicic-Zagar | [[Category: Vannier F]] | ||
[[Category: Vujicic-Zagar A]] | |||