3b9q: Difference between revisions

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-{{Seed}}
-[[Image:3b9q.png|left|200px]]
-<!--
+==The crystal structure of cpFtsY from Arabidopsis thaliana==
-The line below this paragraph, containing "STRUCTURE_3b9q", creates the "Structure Box" on the page.
+<StructureSection load='3b9q' size='340' side='right'caption='[[3b9q]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3b9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B9Q FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
-{{STRUCTURE_3b9q|  PDB=3b9q  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b9q OCA], [https://pdbe.org/3b9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b9q RCSB], [https://www.ebi.ac.uk/pdbsum/3b9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b9q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CFTSY_ARATH CFTSY_ARATH] Signal recognition particle receptor protein. Binds GTP specifically. The GTPase activity is inhibited by the N-terminus of the protein until binding to the thylakoid membrane. Activates the GTPase activity of FFC/cpSRP54 when bound to the cpSRP complex. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids. Might be also functionally linked to the Sec translocation machinery.<ref>PMID:10214972</ref> <ref>PMID:10480939</ref> <ref>PMID:12105232</ref> <ref>PMID:17475780</ref> <ref>PMID:18764927</ref> <ref>PMID:19293157</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b9q_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b9q ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Two GTPases in the signal recognition particle and its receptor (FtsY) regulate protein targeting to the membrane by formation of a heterodimeric complex. The activation of both GTPases in the complex is essential for protein translocation. We present the crystal structure of chloroplast FtsY (cpFtsY) at 1.75 A resolution. The comparison with FtsY structures in different nucleotide bound states shows structural changes relevant for GTPase activation and provides insights in how cpFtsY is pre-organized for complex formation with cpSRP54. The structure contains an amino-terminal amphipathic helix similar to the membrane targeting sequence of Escherichia coli FtsY. In cpFtsY this motif is extended, which might be responsible for the enhanced attachment of the protein to the thylakoid membrane.
-===The crystal structure of cpFtsY from Arabidopsis thaliana===
+The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site.,Stengel KF, Holdermann I, Wild K, Sinning I FEBS Lett. 2007 Dec 11;581(29):5671-6. Epub 2007 Nov 20. PMID:18022392<ref>PMID:18022392</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_18022392}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3b9q" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 18022392 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18022392}}
+__TOC__
+</StructureSection>
-==About this Structure==
-B9Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9Q OCA].
-==Reference==
-<ref group="xtra">PMID:18022392</ref><references group="xtra"/>
 [[Category: Arabidopsis thaliana]]
-[[Category: Sinning, I.]]
+[[Category: Large Structures]]
-[[Category: Stengel, K F.]]
+[[Category: Sinning I]]
-[[Category: Wild, K.]]
+[[Category: Stengel KF]]
-[[Category: Cpftsy]]
+[[Category: Wild K]]
-[[Category: Gtp-binding]]
-[[Category: Nucleotide-binding]]
-[[Category: Protein translocation]]
-[[Category: Protein transport]]
-[[Category: Srp receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:43:06 2009''