3aj5: Difference between revisions

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 ==HA1 (HA33) subcomponent of botulinum type C progenitor toxin complexed with N-acetylgalactosamine, bound at site II==
-<StructureSection load='3aj5' size='340' side='right' caption='[[3aj5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='3aj5' size='340' side='right'caption='[[3aj5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3aj5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AJ5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3aj5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AJ5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ah1|3ah1]], [[3ah2|3ah2]], [[3ah4|3ah4]], [[3aj6|3aj6]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aj5 OCA], [http://pdbe.org/3aj5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aj5 RCSB], [http://www.ebi.ac.uk/pdbsum/3aj5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aj5 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aj5 OCA], [https://pdbe.org/3aj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aj5 RCSB], [https://www.ebi.ac.uk/pdbsum/3aj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aj5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/HA33_CLOBO HA33_CLOBO]] Protects the structural integrity of the neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host. Involved in binding to the small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties.
+[https://www.uniprot.org/uniprot/HA33C_CBCP HA33C_CBCP] Agglutinates human erythrocytes (PubMed:2205574). The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (PubMed:9421908). The hemagglutinin (HA) component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable). Binds galactose or oligosaccharides with galactose at their non-reducing end (PubMed:14663070). Binds eukaryotic host mucins; binding is inhibited by N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine, galactose, and methyl N-acetyl-beta-neuraminic acid (PubMed:18178224). Binds N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine and galactose (but not glucose) via 2 sites (PubMed:18178224, PubMed:21640703).<ref>PMID:14663070</ref> <ref>PMID:18178224</ref> <ref>PMID:21640703</ref> <ref>PMID:2205574</ref> <ref>PMID:9421908</ref> <ref>PMID:9421908</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[Hemagglutinin|Hemagglutinin]]
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Bacillus botulinus van ermengem 1896]]
+[[Category: Clostridium botulinum]]
-[[Category: Nakamura, T]]
+[[Category: Large Structures]]
-[[Category: Nishikawa, A]]
+[[Category: Nakamura T]]
-[[Category: Oguma, K]]
+[[Category: Nishikawa A]]
-[[Category: Sato, R]]
+[[Category: Oguma K]]
-[[Category: Tonozuka, T]]
+[[Category: Sato R]]
-[[Category: Beta-trefoil]]
+[[Category: Tonozuka T]]
-[[Category: Hemagglutinin]]
-[[Category: Toxin]]