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==HA1 subcomponent of botulinum type C progenitor toxin complexed with N-acetylgalactosamine==
==HA1 subcomponent of botulinum type C progenitor toxin complexed with N-acetylgalactosamine==
<StructureSection load='3ah2' size='340' side='right' caption='[[3ah2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3ah2' size='340' side='right'caption='[[3ah2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ah2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ehm 2ehm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AH2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ah2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ehm 2ehm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AH2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qxm|1qxm]], [[3ah1|3ah1]], [[3ah4|3ah4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ah2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah2 OCA], [http://pdbe.org/3ah2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ah2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ah2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ah2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah2 OCA], [https://pdbe.org/3ah2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ah2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ah2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HA33_CLOBO HA33_CLOBO]] Protects the structural integrity of the neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host. Involved in binding to the small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties.  
[https://www.uniprot.org/uniprot/HA33C_CBCP HA33C_CBCP] Agglutinates human erythrocytes (PubMed:2205574). The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (PubMed:9421908). The hemagglutinin (HA) component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable). Binds galactose or oligosaccharides with galactose at their non-reducing end (PubMed:14663070). Binds eukaryotic host mucins; binding is inhibited by N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine, galactose, and methyl N-acetyl-beta-neuraminic acid (PubMed:18178224). Binds N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine and galactose (but not glucose) via 2 sites (PubMed:18178224, PubMed:21640703).<ref>PMID:14663070</ref> <ref>PMID:18178224</ref> <ref>PMID:21640703</ref> <ref>PMID:2205574</ref> <ref>PMID:9421908</ref> <ref>PMID:9421908</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus botulinus van ermengem 1896]]
[[Category: Clostridium botulinum]]
[[Category: Ide, A]]
[[Category: Large Structures]]
[[Category: Nakamura, T]]
[[Category: Ide A]]
[[Category: Nishikawa, A]]
[[Category: Nakamura T]]
[[Category: Oguma, K]]
[[Category: Nishikawa A]]
[[Category: Tonozuka, T]]
[[Category: Oguma K]]
[[Category: Yuzawa, T]]
[[Category: Tonozuka T]]
[[Category: Beta trefoil]]
[[Category: Yuzawa T]]
[[Category: Hemagglutinin]]
[[Category: Toxin]]

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