3af4: Difference between revisions

No edit summary
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with GMPPCP==
==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with GMPPCP==
<StructureSection load='3af4' size='340' side='right' caption='[[3af4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3af4' size='340' side='right'caption='[[3af4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3af4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AF4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3af4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AF4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zse|2zse]], [[2zs8|2zs8]], [[2zs9|2zs9]], [[2zsa|2zsa]], [[2zsb|2zsb]], [[2zsf|2zsf]], [[3aez|3aez]], [[3af0|3af0]], [[3af1|3af1]], [[3af2|3af2]], [[3af3|3af3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3af4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3af4 OCA], [https://pdbe.org/3af4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3af4 RCSB], [https://www.ebi.ac.uk/pdbsum/3af4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3af4 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3af4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3af4 OCA], [http://pdbe.org/3af4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3af4 RCSB], [http://www.ebi.ac.uk/pdbsum/3af4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3af4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COAA_MYCTU COAA_MYCTU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/3af4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/3af4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 31: Line 31:


==See Also==
==See Also==
*[[Pantothenate kinase|Pantothenate kinase]]
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Pantothenate kinase]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chetnani, B]]
[[Category: Chetnani B]]
[[Category: Kumar, P]]
[[Category: Kumar P]]
[[Category: Surolia, A]]
[[Category: Surolia A]]
[[Category: Vijayan, M]]
[[Category: Vijayan M]]
[[Category: Atp-binding]]
[[Category: Coa biosynthesis]]
[[Category: Homodimer]]
[[Category: Kinase]]
[[Category: Nucleotide binding]]
[[Category: Nucleotide-binding]]
[[Category: Transferase]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA