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==High-resolution structure of DHDPS from Clostridium botulinum in complex with pyruvate==
==High-resolution structure of DHDPS from Clostridium botulinum in complex with pyruvate==
<StructureSection load='3a5f' size='340' side='right' caption='[[3a5f]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
<StructureSection load='3a5f' size='340' side='right'caption='[[3a5f]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3a5f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clob1 Clob1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A5F FirstGlance]. <br>
<table><tr><td colspan='2'>[[3a5f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._ATCC_19397 Clostridium botulinum A str. ATCC 19397]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A5F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441770 CLOB1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5f OCA], [https://pdbe.org/3a5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a5f RCSB], [https://www.ebi.ac.uk/pdbsum/3a5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5f ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5f OCA], [http://pdbe.org/3a5f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a5f RCSB], [http://www.ebi.ac.uk/pdbsum/3a5f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5f ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
[[Category: Clostridium botulinum A str. ATCC 19397]]
[[Category: Clob1]]
[[Category: Large Structures]]
[[Category: Atkinson, S C]]
[[Category: Atkinson SC]]
[[Category: Dobson, R C.J]]
[[Category: Dobson RCJ]]
[[Category: Perugini, M A]]
[[Category: Perugini MA]]
[[Category: Amino-acid biosynthesis]]
[[Category: Diaminopimelate biosynthesis]]
[[Category: Enzyme]]
[[Category: Lyase]]
[[Category: Lysine biosynthesis]]
[[Category: Schiff base]]
[[Category: Tim barrel]]

Latest revision as of 17:11, 1 November 2023

High-resolution structure of DHDPS from Clostridium botulinum in complex with pyruvateHigh-resolution structure of DHDPS from Clostridium botulinum in complex with pyruvate

Structural highlights

3a5f is a 2 chain structure with sequence from Clostridium botulinum A str. ATCC 19397. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.19Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3a5f, resolution 1.19Å

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