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==Crystal Structure of Class C beta-Lactamase ACT-1== | ==Crystal Structure of Class C beta-Lactamase ACT-1== | ||
<StructureSection load='2zc7' size='340' side='right' caption='[[2zc7]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2zc7' size='340' side='right'caption='[[2zc7]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zc7]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2zc7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZC7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zc7 OCA], [https://pdbe.org/2zc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zc7 RCSB], [https://www.ebi.ac.uk/pdbsum/2zc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zc7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q48428_KLEPN Q48428_KLEPN] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Beta-lactamase|Beta-lactamase]] | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Klebsiella pneumoniae]] | ||
[[Category: Galleni | [[Category: Large Structures]] | ||
[[Category: Sakai | [[Category: Galleni M]] | ||
[[Category: Shimizu-Ibuka | [[Category: Sakai H]] | ||
[[Category: Shimizu-Ibuka A]] | |||
Latest revision as of 16:31, 1 November 2023
Crystal Structure of Class C beta-Lactamase ACT-1Crystal Structure of Class C beta-Lactamase ACT-1
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystallographic structure of ACT-1, which is the first plasmid-mediated AmpC-type beta-lactamase to have been completely analyzed in terms of nucleotide sequence and which has a high degree of sequence similarity to the chromosomal AmpC enzymes of Enterobacter cloacae and the plasmid-encoded MIR-1, has been solved at 2.4 A resolution. The overall structure of ACT-1 is similar to those of other class C beta-lactamases, such as the AmpC enzymes from E. cloacae P99 and Escherichia coli. Structure of the plasmid-mediated class C beta-lactamase ACT-1.,Shimizu-Ibuka A, Bauvois C, Sakai H, Galleni M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt, 5):334-7. Epub 2008 Apr 5. PMID:18453698[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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