2z7h: Difference between revisions
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-210== | ==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-210== | ||
<StructureSection load='2z7h' size='340' side='right' caption='[[2z7h]], [[Resolution|resolution]] 2.08Å' scene=''> | <StructureSection load='2z7h' size='340' side='right'caption='[[2z7h]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2z7h]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2z7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z7H FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG3:{1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC+ACID)'>GG3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GG3:{1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC+ACID)'>GG3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z7h OCA], [https://pdbe.org/2z7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z7h RCSB], [https://www.ebi.ac.uk/pdbsum/2z7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z7h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 31: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Geranylgeranyl pyrophosphate synthase|Geranylgeranyl pyrophosphate synthase]] | *[[Geranylgeranyl pyrophosphate synthase 3D structures|Geranylgeranyl pyrophosphate synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cao | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Chen | [[Category: Cao R]] | ||
[[Category: Guo | [[Category: Chen CK-M]] | ||
[[Category: Hudock | [[Category: Guo R-T]] | ||
[[Category: Oldfield | [[Category: Hudock M]] | ||
[[Category: Wang | [[Category: Oldfield E]] | ||
[[Category: Wang AH-J]] | |||