Ribosome recycling factor: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (5 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='' size='340' side='right' caption='E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code [[1ek8]])' scene='70/706271/Cv/1' pspeed='8'> | ||
== Function == | == Function == | ||
'''Ribosome recycling factor''' (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis. | '''Ribosome recycling factor''' (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis. | ||
RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation<ref>PMID:16043510</ref>. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA. | RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation<ref>PMID:16043510</ref>. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA. | ||
*<scene name='70/706271/Cv/ | *<scene name='70/706271/Cv/4'>1st Hg coordination site</scene>. | ||
*<scene name='70/706271/Cv/ | *<scene name='70/706271/Cv/5'>2nd and 3rd Hg coordination sites</scene>. Water molecule is shown as red sphere. | ||
</StructureSection> | </StructureSection> | ||
| Line 15: | Line 15: | ||
*Ribosome recycling factor | *Ribosome recycling factor | ||
**[[1wih]] – RRF mitochondrial domain II – mouse - NMR <br /> | |||
**[[1dd5]] – RRF – ''Thermotoga maritima'' <br /> | **[[1dd5]] – RRF – ''Thermotoga maritima'' <br /> | ||
**[[1eh1]] – TtRRF – ''Thermus thermophilus'' <br /> | **[[1eh1]] – TtRRF – ''Thermus thermophilus'' <br /> | ||
| Line 22: | Line 23: | ||
**[[1is1]] – RRF – ''Vibrio parahaemolyticus'' <br /> | **[[1is1]] – RRF – ''Vibrio parahaemolyticus'' <br /> | ||
**[[1wqf]], [[1wqg]], [[1wqh]], [[4kdd]] – MtRRF - ''Mycobacterium tuberculosis''<br /> | **[[1wqf]], [[1wqg]], [[1wqh]], [[4kdd]] – MtRRF - ''Mycobacterium tuberculosis''<br /> | ||
**[[ | **[[4kb2]], [[4kb4]], [[4kc6]], [[4kaw]] – MtRRF (mutant) <br /> | ||
**[[4gfq]] – RRF – ''Bacillus anthracis'' <br /> | **[[4gfq]] – RRF – ''Bacillus anthracis'' <br /> | ||
**[[ | **[[6vud]] – RRF – ''Ehrlichia chafeensis''<br /> | ||
*Ribosome recycling factor in the ribosome | *Ribosome recycling factor in the ribosome | ||
**[[4v54]], [[4v55]], [[4v5y]], [[4v9c]], [[4v9d]] – EcRRF | **[[6nu2]], [[6nu3]], [[6zs9]], [[7l20]], [[7nsi]], [[7nsh]] – hRRF in 38S ribosome – human - Cryo-EM <br /> | ||
**[[1t1m]], [[1zn1]] – EcRRF | **[[7l08]], [[7nqh]], [[7nql]], [[7nsj]] – hRRF in 55S mitoribosome - Cryo-EM <br /> | ||
**[[1zn0]], [[2rdo]] – EcRRF | **[[5mlc]], [[6eri]] – RRF in 50S ribosome – spinach - Cryo-EM <br /> | ||
**[[3j0d]], [[3j0e]] – TtRRF | **[[4v54]], [[4v55]], [[4v5y]], [[4v9c]], [[4v9d]] – EcRRF in 50S ribosome <br /> | ||
**[[4v5a]] – TtRRF | **[[1t1m]], [[1zn1]] – EcRRF in 70S ribosome – Cryo-EM <br /> | ||
**[[1y69]] – RRF | **[[1zn0]], [[2rdo]] – EcRRF in 50S ribosome – Cryo-EM <br /> | ||
**[[4woi]] – EcRRF in 50S ribosome + antibiotic <br /> | |||
**[[3j0d]], [[3j0e]] – TtRRF in Ec50S ribosome – Cryo-EM <br /> | |||
**[[4v5a]], [[6ucq]] – TtRRF in 70S ribosome <br /> | |||
**[[1y69]] – RRF in 50S ribosome – ''Deinococcus radiodurans'' <br /> | |||
**[[7pau]] – RRF in 50S ribosome – ''Mycoplasma pneumoniae'' - Cryo-EM <br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||